Amid of beta-beta-methylpropylpropionic acid.



' To all whom it may concern:

\ barren eras-re ner carton LUDWIG TAUB, OF ELBERFELD, GERMANY, ASSIG'NOR TO FARBENFABRIKEN VORM. FRIEDR. BAYER & (30., OF ELBERFELD, GEPJMANY A CORPORATION OF GERMANY.

AMID OF BETA-BETA-ME'IHYLPROPYLPROPIONIC ACID.

No Drawing.

Specification of Letters. Patent.

Application filed October 21, 1909.

Patented June 1 T6919.

Serial No. 523,805. (Specimens) Be it known that I, LUnwro TAUB doctor of philosophy, chemist, citizen of the German Empire, residing at Elberfeld Germany, have invented new and useful Improvements in .Xmid of BetiuBeta-Methyh propylpropionic Acid, of which the following is a specification.

My invention relates to the manufacture and production of a new valuable pharmaceutical product which is chemically the. amid of beta-beta-mcthylpropyl-propi0nic acid, and which according to my researches is a valuable sedative. For the isomeric amid of beta-beta-diethyl-propionic acid have filed a separate application Serial No. 513,978 dated February 15, 1910.

The new product is a crystalline compound soluble in hot alcohol and hot benzene. hen reacted upon by hot alkalies it is split up into the free acid and mm caustic alkali and monia.

In carrying out my process practically I can proceed as follows, the parts being by weight: 390 parts of methylpropylpropionic acid are heated with 135 parts of phosphorus trichlorid to l()() (I, the liquid is then poured oil from the produced phosphoric acid and distilled in, vac 110. The chlorid of beta-beta-iiiethylpropylpropionic acid which is thus obtained is treated with an excess of ammonia, the amid is filtered (iii and crystallized from benzene. It is a white crystalline powder melting at 99 C. soluble in hot alcohol and hot benzene, liberating the free acid when reacted upon by caustic alkali and exhibiting valuable sedative properties, an average dose being about to 1 ram.

The reaction probably takes place according to the following formulae:

CH3 CH3 on 1 3 on-cn ooon+eon=a on-cugooci+r on can c n, \on

2 on-cHQooc1+N Hi:

C3117 C1l'i7 I claim The herein described new amid of betabet a-methylpropylpropionic acid being a white crystalline powder melting at 99 (7., soluble in hot alcohol and hot benzene, liberating the free acid when reacted upon by exhibiting Valuable sedative properties, substantially as described.

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

LUDVIG TAUB, \L. s.]

Witnesses OTTO Koxro,

Cims. J. lNliion'r. 

